Quick answer
Numbers do not change the outcome. Collaboration can make wickedness effective for a while, and the verse says it cannot make it safe.
Read both lines
The NKJV footnotes the first phrase as literally hand to hand, an idiom of agreement or alliance, so the picture is people combining. What the verse denies is that the combination alters anything, which is a real comfort when the wrong side looks organized and the right side looks outnumbered. The second line extends the horizon past the individual to descendants, which is characteristic of a book written for people thinking in generations rather than quarters.
Related: Proverbs 16:5 · Proverbs 11:8 · Isaiah 8:9–10
New King James Version®, Copyright © 1982, Thomas Nelson. All rights reserved. Full copyright information. Scripture provided by API.Bible.
Go Deeper
If this verse has been used to put weight on you that it was never carrying, ask about it directly.